<i>N</i>-Acetylation of methyl hydrazones with acetic acid in presence of PdCl₂

Organic compounds such as acetic anhydride or acetyl chloride are generally used to form amide bonds by the acetylation of a nitrogen atom. However, it is not possible use this traditional method for hydrazine derivatives. In article, new synthesis has been developed formation bond via methyl hydrazones with acid. development unprecedented method, more than one catalyst was Lewis PdCl2 identified most suitable reaction. addition, solvent experiment carried out optimization and experiments were provide optimal conditions loading. applicability various hydrazone derivatives tested. The structures nine bond-containing acetylated prepared elucidated using 1D-NMR, 2D-NMR, LCMS X-Ray.